Blimey, this release must be a small nightmare for Microsoft, it seems PCs running corporate security software Morphisec Protector or applications that make use of Morphisec technology will be blocked from installing the latest large Windows 10 update. 

Microsoft updated its support page stating it will block some computers from installing the October Update again. reports myce;

Microsoft explains the reason on its website, “Microsoft and Morphisec have identified an issue on devices that have installed Morphisec Protector or another application that uses the Morphisec Software Development Kit (SDK) including:  Cisco AMP for Endpoints. These applications may impact customers’ ability to save Microsoft Office documents.”

Microsoft recommends users who want to install the October 2018 Update to temporarily uninstall the affected software and then install an updated version of the software once its available. The company also states it’s working with Morphisec and Cisco on fixing the issue.

Microsoft again halts October 2018 Update on some PCs