While the TitanX block should work fine, EK outted a press release indicating they are releasing EK-FC1080 GTX Ti water blocks that are compatible with multiple GeForce GTX 1080 Ti based graphics cards. 

Customers will be able to transform their GPU into a stunningly beautiful single slot graphics card and the block will allow reaching higher boost clocks, thus providing more performance during gaming or other GPU intense tasks.

This water block directly cools the GPU, RAM as well as VRM (voltage regulation module) as water flows directly over these critical areas, thus allowing the graphics card and it’s VRM to remain stable under full load and high overclocks. EK-FC1080 GTX Ti water block features a central inlet split-flow cooling engine design for best possible cooling performance, which also works flawlessly with reversed water flow without adversely affecting the cooling performance. Moreover, such design offers great hydraulic performance allowing this product to be used in liquid cooling systems using weaker water pumps.

The base of the block is made of nickel-plated electrolytic copper while the top is made of a high-quality acrylic material or POM Acetal material (depending on the variant). The top material does not affect the block performance in any way. The acrylic (Plexi) top also features two pre-drilled slots for 3mm LED diodes.
 

 
The block also features a special plastic cover over the block Terminal. This add-on is designed to reveal the graphics card model, visible from the side. EK also encloses a single-slot I/O bracket which replaces the original two-slot in order to make installation of multiple graphics cards easier and also transforms the GPU into a gorgeous single slot solution.

EK-FC1080 GTX Ti water block is compatible with multiple GeForce® GTX 1080 Ti graphics cards on the market (see the Compatibility list below).