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At the right top side there is space for three tool-free 5.25in drives, with easy drive installation. Each features a latch that has an 'open' and 'lock' position. You simply pull and release the latch. That really works just great, mounting a 5.25" device could not be any easier - just line up the holes on the optical drive you just inserted into the case and when you hear a click the pin locks have secured the device. Aesthetically things will change a little though as there will be an indentation once you use the 5.25" devices, so the front is not 100% flat once you insert a 5.25" optical device or whatever.

Standard ATX sized PSUs will fit just fine up-to roughly 18cm, then add to that some cables and you'll notice that one drive cage can get in the way. You can remove it though, totally your call. The PSUs will rest on inserts preventing them from resonating. 

The 750D comes standard with two 3.5" HDD cages which support three 3.5 inch or 2.5 inch drives each in any combination. Here's how you install the actual HDD.

You can easily insert and/or remove these. You place the HDD in a tray, slide it backwards in the cage and secure it with the hinge. It is as simple as that. The HDD hangs in rubber inserts. One such tray can be used for an SSD as well, these are secured with four screws at the bottom side of the tray. But again let me mention that there is a cage especially for 2.5" devices.